Paralyzed Dogs Walk Again After Nose Cell Transplant

Paralyzed Dogs Walk Again After Nose Cell TransplantScientists have reversed paralysis in dogs after injecting them with cells grown from the lining of their nose. The pets had all suffered spinal injuries which prevented them from using their back legs. The Cambridge University team is cautiously optimistic the technique could eventually have a role in the treatment of human patients.

‘Considerable improvement’

In the study, funded by the Medical Research Council and published in the neurology journal Brain, the dogs had olfactory ensheathing cells from the lining of their nose removed. These were grown and expanded for several weeks in the laboratory. Of 34 pet dogs on the proof of concept trial, 23 had the cells transplanted into the injury site – the rest were injected with a neutral fluid. Many of the dogs that received the transplant showed considerable improvement and were able to walk on a treadmill with the support of a harness. None of the control group regained use of its back legs.


‘Human patients’

The research was a collaboration between the MRC’s Regenerative Medicine Centre and Cambridge University’s Veterinary School. Professor Robin Franklin, a regeneration biologist at the Wellcome Trust-MRC Stem Cell Institute and report co-author, said:

“We’re confident that the technique might be able to restore at least a small amount of movement in human patients with spinal cord injuries but that’s a long way from saying they might be able to regain all lost function. ‘

The researchers say the transplanted cells regenerated nerve fibres across the damaged region of the spinal cord. This enabled the dogs to regain the use of their back legs and coordinate movement with their front limbs. The new nerve connections did not occur over the long distances required to connect the brain to the spinal cord. The MRC scientists say in humans this would be vital for spinal injury patients who had lost sexual function and bowel and bladder control.

Do you find this study promising for spinal injury patients? Tell us what you think of the results of this research!

Source: BBC News

Image: Popsci

Record-Breaking Wine To Be Sold At $168K Per Bottle

The most expensive wine ever sold directly from a winery will go on sale this week, from the venerable Australian vintner Penfolds. The limited edition release of the 2004 Penfolds Block 42 Cabernet Sauvignon is priced at $168,000 a bottle.

The wine’s distinctive price comes from its rarity. The wine was made from the oldest producing cabernet sauvignon vines in the world, transplanted from France to Australia in the 1830s. Later planted at the Kalimna Vineyard in the Barossa Valley, northeast of Adelaide, the vines today provide unequaled juice, but little of it. Only 12 bottles of the 2004 vintage will be sold.

To add further cachet, Penfolds commissioned an ampoule of scientific grade glass to hold it from three Australian artists: Nick Mount, who designed and hand-blew the glass; silversmith Hendrik Forster, who prepared the precious metal detailing; and furniture craftsman Andrew Bartlett, made the bespoke Jarrah cabinet.


“Wine and art are intrinsically linked,” says Matt Lane, Penfolds’s U.S. representative, making the ideal buyer, says Lane, is “a big time, serious wine collector, of course, but also the art aficionado who wants to collect a unique sculpture.”

The other attribute of the ideal buyer – profoundly deep pockets – is indicated by the 12 bottles’ allocation for sale: three will go to Russia, London and Dubai, three to the rest of Asia, two to North America, and two to Australia. (One bottle will be donated to a charitable organization for auction, while the remaining one will be kept at Penfolds as a showpiece.) It’s more likely the buyers of the historic bottles will hang onto them as part of a larger oenophilic portfolio.

What meal would you eat with if you were to drink this $168-grand wine? Would you spend as much for an exquisite bottle of wine? Share your most luscious dishes in mind for this over-the-top beverage!

Source: Yahoo News

Image: Business Week